Ultrasound Assisted Endoscopic Gastric Bypass (USA-EGB): a potential endoscopic alternative to surgical bypass, a pre-clinical proof of concept study

Abstract Background and study aims Endoscopic weight loss procedures have gained traction as minimally invasive options for the primary treatment of obesity. Thus far, we developed endoscopic that reliably address gastric restriction but result in significantly less than surgical gastrointestinal bypass. The goal this nonsurvival was to assess technical feasibility an procedure, incorporates both potentially reversible Methods Ultrasound-assisted bypass (USA-EGB) performed three consecutive live swine, followed by euthanasia necropsy. Procedure steps were: 1) balloon-assisted enteroscopy determines length bypassed limb; 2) ultrasound-guided gastroenterostomy creates a anastomosis using lumen apposing metal stent; 3) pyloric exclusion disrupts transpyloric continuity resulting complete bypass; 4) reduces volume. Results Complete achieved all swine. mean total procedure time 131 minutes (range 113–143), limb 92.5 cm 180 cm, short long overtubes, respectively. There were no significant complications. Conclusions We successfully described USA-EGB Further studies are needed access safety, efficacy, clinical use.